The four-layer hierarchy Context Registry | Governance | Evaluation cycle Operational environment where systems are deployed, discovered, and governed Layer 4 Biology Agentic system as cell | Membrane | Nucleus | Organelles Bounded, self-regulating systems with lifecycle properties Layer 3 Chemistry Tool molecules | Agent molecules | Orchestrators Bonding rules governing valid compositions. First emergence. Layer 2 Physics 22 elements (P1–P6) + 3 bosons + 2 predicted gaps Irreducible building blocks. The periodic table. Layer 1 depends upward Layer 0: sub-atomic substrate (CPU, GPU, RAM, Storage, Network) — beneath the table